So that could be by upgrading runes already in an item or crafting unset runes in a device with reagents or multiples of the same rune combining to ‘upgrade’ the rune.

Blizzard also appears to be using the same names and some of the visual representations of the rune symbols as seen in Diablo 2. It’s unclear if all the 33 different runes from Diablo 2 will be the same in Diablo 4. However, some have been identifies as shown in the list below.

Some of the Diablo 4 runes have been confirmed already but note, the socketed properties in Diablo 4 are different from the properties in Diablo 2. Below is a list of all the expected runes based on the Diablo 2 runes. The list shows confirmed runes for Diablo IV and their new properties.

Known Diablo 4 Runes

Rune Diablo 4 Confirmed Condition /

Effect

Socketed Properties
El
El rune.sprite.00.png
Eld
Eld Rune
X Condition When you are stunned or frozen, activate the next socketed rune
Tir
Tir Rune
Nef
Nef Rune
Eth
Eth Rune
X Condition Every 3 seconds without moving, activate the next socketed rune
Ith
Ith Rune
Tal
Tal Rune
Ral
Ral Rune
Ort
Ort Rune
Thul
Thul Rune
X Effect When active, gain 500 damage barrier
Amn
Amn Rune
X Condition When you freeze an enemy, activate the next socketed rune.
Sol
Sol Rune
X Effect When active, gain a random shrine effect for 7 seconds
Shael
Shael Rune
Dol
Dol Rune
X Effect When active, gain 50% critical strike chance for 7 seconds
Hel
Hel Rune
Io
Lo Rune
Lum
Lum Rune
Ko
Ko Rune
X Effect When active, reduce a random skill cooldown by 15%
Fal
Fal Rune
X Condition When a pet dies, activate the next socketed rune
Lem
Lem Rune
Pul
Pul Rune
Um
Um Rune
Mal
Mal Rune
Ist
Ist Rune
X Effect When active, your next thorns hit deals 30% more
Gul
Gul Rune
Vex
Vex Rune
X Condition When you use a healing potion, activate the next socketed rune
Ohm
Ohm Rune
Lo
Lo Rune
Sur
Sur Rune
Ber
Ber Rune
Jah
Jah Rune
Cham
Cham
Zod
Zod